Solitary plasmacytoma, in contrast to the disseminated neoplastic proliferation of plasma cells with marked infiltration of multiple organ system in multiple myeloma, is plasma cell neoplasm of a single focus occuring either in bone or soft
tissue.
The
association between a solitary plasmacytoma and peripheral neuropathy is rare, and it is a progressive sensorimotor neuropathy, with a raised CSF protein and mixed demyelination and axonal loss in nerve biopsy. Localized radiotherapy indeed
proves
to be
effective of not only arresting the progress of the neuropathy but also allowing a degree of recovery.
We experienced a 55-year-old male with a solitary palmacytoma and peripheral neuropathy confirmed by the radiologic studies, immunohistochemical stain of nasopharyngeal mucosa biopsy and sural nerve biopsy, which as loss of myelinated fiber and
axonal
degeneration. Until now, the reported cases are very rare in Korea, so we presented a case of solitary plasmacytoma associated with peripheral neuropathy.
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